THE IN VITRO METABOLISM OF Al - ANDROSTENEDIONE

نویسندگان

  • LELAND C. CLARK
  • CHARLES D. KOCHAKIAN
  • JULIA LOBOTSKY
چکیده

It has been demonstrated in this laboratory (1) that A4-androstenedione3,17, c&testosterone, and small amount of other unidentified steroids are formed when testosterone is incubated with liver slices. In order to elucidate further the course of the metabolism of these steroids, 2000 mg. of A4-androstenedione-3, 17, the chief metabolite of testosterone (l), has been incubated in lots of 100 mg. per 10 gm. of liver slices with sterile precautions. The procedure, gross extraction, and fractionation were identical to those employed in the first study.

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تاریخ انتشار 2003